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KMID : 0363220110490050440
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Korean Journal of Dermatology
2011 Volume.49 No. 5 p.440 ~ p.443
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Scleromyxedema with Monoclonal Gammopathy
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Shim Hyun-Chul
Kim Geon
Choi Ji-Hyun
Kim Ji-Hye
Kim Eun-Jung
Park Hyang-Joon
Joh Ok-Ja
Song Kye-Yong
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Abstract
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Scleromyxedema is a rare disorder characterized by generalized papular and sclerodermoid eruption, increased fibroblast proliferation, mucin deposition, and monoclonal gammopathy in the absence of thyroid disease. It is a generalized subtype of lichen myxedematosus. A paraproteinemia, typically an IgG λ, is observed in more than 80% of patients with scleromyxedema. Here, we report a 38-year-old woman with a 1-year history of a progressively spreading of eruption of small papules on the entire body, including the face, neck, arms, legs, and trunk. Laboratory tests were within normal limits, except λ light chain monoclonal gammopathy. We administered oral retinoid and topical steroid with slight clinical improvement. To our knowledge, this is the first reported case of scleromyxedema in Korea.
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KEYWORD
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Lichen myxedematosus, Monoclonal gammopathy, Scleromyxedema
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